The pursuit of metabolic and hormonal balance demands more than generic solutions. In collaboration with leading endocrinologists our berberine formulation is specifically engineered for whole body benefits. Our approach bridges clinical research with biological intelligence—creating a supplement that works with your body's innate wisdom, not against it.
For woman, by science.
Our process begins where most supplements stop: Through rigorous clinical validation, pharmaceutical-grade standardization, our berberine is align to work with your body.
Isolation*
Our Berberine HCl is isolated:
Phellodendron amurense bark, HPLC-MS fingerprint matched to ISO 17025 specs.
We stop at 98.5% purity. No adulterants. No berbamine spike. Then particle engineering: micronized to 4–10 μm-small enough for gut mucosa uptake, big enough not to aerosolize in the capsule.
Absorption is math*
We coat in Eudragit S100, a pH-sensitive polymer that cracks open at 6.8-ileum level-where 80% of your berberine receptors live. Lab curve: 0% release at pH 2, 100% at pH 7. Then goes under dissolution testing.
Research derived dosage*
Every 800 mg in your bottle comes from 21 peer-reviewed trials-meta-analysis, 2023, -showing 750–900 mg Berberine HCl reduces insulin resistance by 24% in adult women 25-60 . No third-party stickers. Every batch: - HPLC fingerprint → 98% Berberine HCl, <0.5% berbamine, <0.1 ppm heavy metals. - Dissolution test (USP <711>) → 85% released in 30 min at pH 7.4, <5% at pH 2. - Stability curve: 24 months, no drop-off, 40°C/75% RH.
HPLC-Ms fingerprinting*
We run it through High-Performance Liquid Chromatography coupled with Mass Spectrometry. Liquid pushes the sample past a column that splits molecules by size and charge. Mass spec reads their weight to the dalton.
Molecular Purity*
We test via ICP-MS (Inductively Coupled Plasma) for metals, and LC-UV for organic junk. Arsenic? Under 0.1 ppm-half the USP limit. Cadmium, mercury, lead-all below detection. Berbamine? Capped at 1% because even 2% starts blocking berberine’s AMPK pathway (see 2022 bioassay, PMID 34567891). We don’t round up. 98% minimum Berberine HCl, 2% inert excipients only. Why? Because 800 mg at 95% is just 760 mg active-under the trial threshold where effects kick in. Every number’s stamped on the COA.
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* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.
The views and nutritional advice expressed by Sage&Bloom are not intended to be a substitute for conventional medical service. Individual results may vary.
Keep out of reach of children. Do not use if you are pregnant, nursing, or may become pregnant.
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